The Clostridium difficile cpr locus is regulated by a noncontiguous two-component system in response to type A and B lantibiotics.

@article{Suarez2013TheCD,
  title={The Clostridium difficile cpr locus is regulated by a noncontiguous two-component system in response to type A and B lantibiotics.},
  author={Jose M. Saro Suarez and Adrianne Nehrling Edwards and Shonna M McBride},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 11},
  pages={
          2621-31
        }
}
The intestinal pathogen Clostridium difficile is known to grow only within the intestines of mammals, yet little is known about how the bacterium subsists in this environment. In the intestine, C. difficile must contend with innate defenses within the host, such as cationic antimicrobial peptides (CAMPs) produced by the host and the indigenous microbiota. In this study, we investigated the mechanism of activation and regulation of the CprABC transporter system, which provides resistance to… CONTINUE READING
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2630 jb.asm.org Journal of Bacteriology

TJ Oman, JM Boettcher, H Wang, XN Okalibe, WA SuárezvanderDonk
  • Nat. Chem. Biol
  • 2011
VIEW 2 EXCERPTS

Risk factors associated with complications and mortality in patients with Clostridium difficile infection.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2011