The ClockΔ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine.


BACKGROUND Clock genes have been demonstrated to play a role in behavioral responses to a variety of drugs of abuse, including cocaine, amphetamine, morphine, and ethanol. However, no studies to date have examined the role of Clock genes on nicotine-mediated behaviors. We examined the involvement of Clock, one of several Clock genes, on the effects of… (More)
DOI: 10.1016/j.drugalcdep.2013.08.024