The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

@article{Colwill1996TheCP,
  title={The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.},
  author={Karen Colwill and Tony J. Pawson and Brenda Andrews and Jayendra Prasad and James L Manley and John C. Bell and Peter I. Duncan},
  journal={The EMBO journal},
  year={1996},
  volume={15 2},
  pages={265-75}
}
Mammalian Clk/Sty is the prototype for a family of dual specificity kinases (termed LAMMER kinases) that have been conserved in evolution, but whose physiological substrates are unknown. In a yeast two-hybrid screen, the Clk/Sty kinase specifically interacted with RNA binding proteins, particularly members of the serine/arginine-rich (SR) family of splicing factors. Clk/Sty itself has an serine/arginine-rich non-catalytic N-terminal region which is important for its association with SR splicing… CONTINUE READING
Highly Influential
This paper has highly influenced 25 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 182 extracted citations

Similar Papers

Loading similar papers…