The Clinical Pharmacology of BW A444U A Nondepolarizing Ester Relaxant of Intermediate Duration

@article{Savarese1983TheCP,
  title={The Clinical Pharmacology of BW A444U A Nondepolarizing Ester Relaxant of Intermediate Duration},
  author={J. Savarese and H. Ali and S. Basta and N. Sunder and J. Moss and M. Gionfriddo and C. Lineberry and W. Wastila and H. A. El-Sayad and D. Montague and L. Braswell},
  journal={Anesthesiology},
  year={1983},
  volume={58},
  pages={333–341}
}
  • J. Savarese, H. Ali, +8 authors L. Braswell
  • Published 1983
  • Medicine
  • Anesthesiology
  • The clinical pharmacology of BW A444U, a nondepolarizing ester relaxant, was evaluated in 56 consenting ASA class I subjects under nitrous oxide/oxygen-fentanyl-thiopental anesthesia. Using repetitive train-of-four stimulation, the ED95 for inhibition of the first twitch in the train (T1) was 0.11 mg/kg. At 0.12 mg/kg, 97% inhibition of T1 developed within 4.6 ± 0.6 (SE) min from injection; recovery of T1 to 95% of the control height occurred within 52.3 ± 3.1 min. In a comparative group of… CONTINUE READING
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