The Clinical Pharmacology of Anastrozole

@article{Bao2011TheCP,
  title={The Clinical Pharmacology of Anastrozole},
  author={Ting Bao and Michelle A. Rudek},
  journal={European Oncology and Haematology},
  year={2011},
  volume={07},
  pages={106}
}
  • T. BaoM. Rudek
  • Published 2011
  • Medicine
  • European Oncology and Haematology

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Cytotoxic effect of transdermal invasomal anastrozole gel on MCF-7 breast cancer cell line

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Biodegradable nano-tools that deliver anastrozole to the target site with an increase in its half-life to 144 hours are a promising method and can be achieved by using a transdermal anast rozole administration system, which is a completely non-invasive method of treatment.

EFFECTS OF ANASTROZOLE ADMINISTRATION ON SERUM ESTROGEN LEVEL OF FEMALE RABBIT

Assessment of the effects of anastrozole use as hormonal treatment of breast cancer on the serum estrogen level in an animal model found the decrease is significant statistically and the comparison of the serumosterone levels of both the experimental groups B and C was found to be statistically insignificant.

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FUNGAL KAYNAKLI BASSİATİN’İN (3R,6R) MEME KANSERİ HÜCRE HATLARI ÜZERİNDEKİ ETKİSİNİN ARAŞTIRILMASI

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References

SHOWING 1-10 OF 32 REFERENCES

A Randomized Trial of Letrozole in Postmenopausal Women after Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer

As compared with placebo, letrozole therapy after the completion of standard tamoxifen treatment significantly improves disease-free survival.

A Phase III trial comparing anastrozole (1 and 10 milligrams), a potent and selective aromatase inhibitor, with megestrol acetate in postmenopausal women with advanced breast carcinoma

The efficacy and tolerability of anastrozole and megestrol acetate were compared in 386 postmenopausal women with advanced breast carcinoma who progressed after tamoxifen therapy.

POTENCY AND SELECTIVITY OF THE NON‐STEROIDAL AROMATASE INHIBITOR CGS 16949A IN POSTMENOPAUSAL BREAST CANCER PATIENTS

It is concluded that CGS 16949A is a potent oestrogen suppressant in postmenopausal patients but that its effect is not totally selective.

Anastrozole and quinapril can be safely coadministered to elderly women with breast cancer and hypertension: a pharmacokinetic study.

It can be concluded that ACE and ANG II activity independently modulate aromatase activity and this suggests a new physiological role for ACE and Angiotensin II.

The effect of anastrozole on the single-dose pharmacokinetics and anticoagulant activity of warfarin in healthy volunteers.

Overall, there was no evidence to suggest that anastrozole has any clinically relevant effects on the pharmacokinetic and pharmacodynamic effects of warfarin.

Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: preliminary results of the Italian Tamoxifen Anastrozole Trial.

Switching to anastrozole after the first 2 to 3 years of treatment is well tolerated and significantly improves event-free and recurrence-free survival in postmenopausal patients with early breast cancer.

Liver toxicity after treatment with gefitinib and anastrozole: drug-drug interactions through cytochrome p450?