The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System

@article{Becher2001TheCC,
  title={The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System},
  author={Burkhard Becher and Brigit G. Durell and Amy V. Miga and William F. Hickey and Randolph J. Noelle},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={193},
  pages={967 - 974}
}
Although it is clear that the function of CD40 on peripheral hematopoietic cells is pivotal to the development of autoimmunity, the function of CD40 in autoimmune disease outside this compartment is unresolved. In a model of experimental autoimmune encephalomyelitis (EAE), evidence is presented that CD40-CD154 interactions within the central nervous system (CNS) are critical determinants of disease development and progression. Using bone marrow (BM) chimeric mice, the data suggest that the lack… CONTINUE READING
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