The Clinical Applications of Extended-Release Abuse-Deterrent Opioids

  title={The Clinical Applications of Extended-Release Abuse-Deterrent Opioids},
  author={Nalini Vadivelu and Erika Schermer and Gopal Kodumudi and Jack M. Berger},
  journal={CNS Drugs},
Opioids are the mainstay for treatment of acute pain and cancer pain, and also have a role in the treatment of chronic non-malignant pain. There has been, however, a growing public health problem stemming from the misuse of opioid analgesics leading to serious consequences. To deter abuse, new formulations of extended-release opioid analgesics and tamper-resistant opioids have recently been developed. The concept of abuse-deterrent extended-release opioids is relatively new and, although abuse… 

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