The Clinical Application of MicroRNAs in Infectious Disease

  title={The Clinical Application of MicroRNAs in Infectious Disease},
  author={Ruth Elizabeth Drury and Daniel O'connor and Andrew J. Pollard},
  journal={Frontiers in Immunology},
MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging that miRNAs are key mediators of the host response to infection, predominantly by regulating proteins involved in innate and adaptive immune pathways. miRNAs can govern the cellular tropism of some viruses, are implicated in the resistance of some individuals to infections like HIV, and are associated with impaired vaccine response… 

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