The Claudin Superfamily Protein NSY-4 Biases Lateral Signaling to Generate Left-Right Asymmetry in C. elegans Olfactory Neurons


Early in C. elegans development, signaling between bilaterally symmetric AWC olfactory neurons causes them to express different odorant receptor genes. AWC left-right asymmetry is stochastic: in each animal, either the left or the right neuron randomly becomes AWC(ON), and the other neuron becomes AWC(OFF). Here we show that the nsy-4 gene coordinates the… (More)
DOI: 10.1016/j.neuron.2006.06.029


7 Figures and Tables