The Claudin Superfamily Protein NSY-4 Biases Lateral Signaling to Generate Left-Right Asymmetry in C. elegans Olfactory Neurons

@article{VanHoven2006TheCS,
  title={The Claudin Superfamily Protein NSY-4 Biases Lateral Signaling to Generate Left-Right Asymmetry in C. elegans Olfactory Neurons},
  author={Miri K VanHoven and Sarah L. Bauer Huang and Stephanie D. Albin and Cornelia I Bargmann},
  journal={Neuron},
  year={2006},
  volume={51},
  pages={291-302}
}
Early in C. elegans development, signaling between bilaterally symmetric AWC olfactory neurons causes them to express different odorant receptor genes. AWC left-right asymmetry is stochastic: in each animal, either the left or the right neuron randomly becomes AWC(ON), and the other neuron becomes AWC(OFF). Here we show that the nsy-4 gene coordinates the lateral signaling that diversifies AWC(ON) and AWC(OFF) neurons. nsy-4 mutants generate 2 AWC(OFF) neurons, as expected if communication… CONTINUE READING
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