The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids (*)

@article{Rigotti1995TheCB,
  title={The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids (*)},
  author={Attilio Rigotti and Susan L. Acton and Monty Krieger},
  journal={The Journal of Biological Chemistry},
  year={1995},
  volume={270},
  pages={16221 - 16224}
}
The specific recognition of anionic phospholipids in the outer leaflets of cell membranes and lipoproteins by cell surface receptors may play an important role in a variety of physiologic and pathophysiologic processes (e.g. recognition of damaged or senescent cells by the reticuloendothelial system or lipoprotein homeostasis). Several investigators have described anionic phospholipid binding to cells, and phosphatidylserine (PS) binding to a partially purified 95-kDa membrane protein has… 

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References

SHOWING 1-10 OF 42 REFERENCES

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

TLDR
It is suggested that the OxLDL receptor plays a significant role in recognition of damaged and apoptotic cells.

Isolation of the thrombospondin membrane receptor.

TLDR
An 88-kD membrane glycoprotein present in platelets, endothelial cells, monocytes, and a variety of human tumor cell lines that is the membrane binding site for TSP is identified and isolated and may function as the cellular TSP receptor.

Chinese Hamster Ovary Cells Expressing a Novel Type of Acetylated Low Density Lipoprotein Receptor

TLDR
It is concluded that the isolated CHO cells express a novel type of AcLDL receptor, which is distinct from macrophage scavenger receptors with respect to ligand specificity and competitor sensitivity.

Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.

TLDR
The purpose of the present review is to summarize the current status of knowledge of CD36, which is the generic term the authors will use in this review for this important glycoprotein.

Phosphatidylserine as a determinant of reticuloendothelial recognition of liposome models of the erythrocyte surface.

TLDR
These results exclude alterations in phospholipid packing as an indirect cause of increased clearance of PtdSer-containing liposomes and implicate PTDSer directly in recognition by the reticuloendothelial system.