The Clarification of Bioreactor Cell Cultures for Biopharmaceuticals

  title={The Clarification of Bioreactor Cell Cultures for Biopharmaceuticals},
  author={David Yavorsky and Robert Blanck and Charles Lambalot and Roger Brunkow},
nant therapeutic proteins, monoclonal antibodies, and vaccines requires choosing a sequence of operations that ensures high yield, product consistency, and reproducibility. Depth, or pad, filtration is gaining acceptance as one technique for the removal of cells, cell debris, colloids, insoluble precipitants, aggregates, and other materials found in mammalian-cell and bacterial fermentation broths. One or more depth filters can be used in a clarification sequence to optimize the filtration with… CONTINUE READING


Publications referenced by this paper.
Showing 1-4 of 4 references

Selection and Sizing of Clarification Depth Filters,

  • D. P. Yavorsky, S. McGee
  • Genetic Eng. News
  • 2002

Assessment of a Disk Stack Centrifuge for use in MammalianCell Separations

  • B. W. Preissmann
  • Biotechnol . Bioeng .
  • 1995

Preissmann, “Assessment of a Disk Stack Centrifuge for use in Mammalian-Cell Separations,

  • B.W.R. Kempken
  • Biotechnol. Bioeng
  • 1995

Vmax Testing for Practical Microfiltration Train Scale-Up in Biopharmaceutical Processing,

  • F. Badmington
  • BioPharm
  • 1995

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