The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells.

@article{Li2002TheCC,
  title={The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells.},
  author={Xinhua Li and Ting Wang and Zhifang Zhao and Steven A. Weinman},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={282 6},
  pages={
          C1483-91
        }
}
ClC-3 is a voltage-gated Cl- channel that is highly conserved and widely expressed, although its function, localization, and properties remain a matter of considerable debate. In this study, we have shown that heterologous expression of ClC-3 in either Chinese hamster ovary (CHO-K1) or human hepatoma (Huh-7) cells results in the formation of large, acidic vesicular structures within cells. Vesicle formation is prevented by bafilomycin, an inhibitor of the vacuolar ATPase, and is not induced by… CONTINUE READING
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