The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma.

@article{Qiu2018TheCR,
  title={The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma.},
  author={Mantang Qiu and Wenjia Xia and Rui Chen and Siwei Wang and Youtao Xu and Zhifei Ma and Weizhang Xu and Erbao Zhang and Jie Wang and Tian Fang and Jingwen Hu and Gaochao Dong and Rong Yin and Jun Wang and Lin Xu},
  journal={Cancer research},
  year={2018},
  volume={78 11},
  pages={
          2839-2851
        }
}
Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we identify a proto-oncogenic circular RNA (circPRKCI) from the 3q26.2 amplicon, one of the most frequent genomic aberrations in multiple cancers. circPRKCI was overexpressed in lung… CONTINUE READING

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