The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

  title={The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study},
  author={Keiji Fukuda and Stephen E. Straus and Ian B. Hickie and Michael Sharpe and James Goodman Dobbins and Anthony L. Komaroff},
  journal={Annals of Internal Medicine},
We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons with unexplained fatigue; the identification of underlying conditions that may explain the presence of chronic fatigue; revised criteria for defining cases of the chronic fatigue syndrome; and a strategy for dividing the chronic fatigue syndrome and other unexplained cases of chronic fatigue into… 

Chronic fatigue syndrome: a review.

This review summarizes the current state of knowledge about chronic fatigue syndrome and suggests that physiological and psychological factors work together to predispose an individual to the illness and to precipitate and perpetuate the illness.

Clinical Practice: Chronic fatigue syndrome

The diagnosis CFS should be considered in any adolescent patient with severe disabling long-lasting fatigue, and cognitive behavioural therapy is effective in 60–70 % of the patients.

The Case Definition of Chronic Fatigue Syndrome

It is suggested that if clinical and laboratory-based studies on chronic fatigue syndrome were conducted on more homogeneous subgroups of patients, the data from one center to the other might not be as conflicting and more insights can be shed on the nature of this clinical condition.

Chronic fatigue syndrome: aetiology, diagnosis and treatment

The main social and care needs for people affected with Chronic Fatigue Syndrome are pointed out to point out to prevent the problems derived from current systems.

Chronic fatigue syndrome: the physiology of people on the low end of the spectrum of physical activity?

In this issue of Clinical Science, McCully and Natelson report data which suggest that there is a reduced capacity for oxygen transport to a lower leg muscle following both exercise and cuff ischaemia in agroup of patients with CFS when compared with a group of controls.

An examination of the working case definition of chronic fatigue syndrome.

Diagnosis of Chronic Fatigue Syndrome in Children and Adolescents

Results would suggest that chronic fatigue syndrome exists in children who presented for evaluation of chronic unexplained fatigue over a two year period, and diagnosis was based upon the 1988 CDC criteria or clinical criteria based upon activity limitation and the associated symptom complex.

Chronic fatigue syndrome: progress and possibilities

A growing body of evidence suggests CFS arises from functional (non‐structural) changes in the brain, but of uncertain character and location, and there is significant room for improvement in provision of the diagnosis and supportive care.

Chronic fatigue syndrome: diagnosis and treatment.

Treatment options include cognitive behavior therapy and graded exercise therapy, both of which have been shown to moderately improve fatigue levels, work and social adjustment, anxiety, and postexertional malaise.

Chronic fatigue and chronic fatigue syndrome: shifting boundaries and attributions.

  • A. Lloyd
  • Medicine, Psychology
    The American journal of medicine
  • 1998



Estimating the prevalence of chronic fatigue syndrome and associated symptoms in the community.

An estimate of the prevalence in the population is presented, approximating the Centers for Disease Control criteria as well as the prevalence estimates of the fatigue symptom complex that include fatigue, disability, and neuromuscular and neuropsychological symptoms.

Chronic fatigue syndrome criteria. A critique of the requirement for multiple physical complaints.

The data suggest that the current case definition for chronic fatigue syndrome inadvertently selects for patients with the highest prevalence of lifetime psychiatric diagnoses, which could lead to modifications of the case criteria to include patients with fatigue and few physical symptoms.

Chronic fatigue syndrome: a working case definition.

A new name is proposed for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue.

Dimensional assessment of chronic fatigue syndrome.

The treatment of chronic fatigue syndrome: science and speculation.

Can the chronic fatigue syndrome be defined by distinct clinical features?

Clinical heterogeneity among patients currently diagnosed as CFS is demonstrated, suggesting aetiological heterogeneity, in the absence of discriminative clinical features, current consensus criteria do not necessarily reduce the heterogeneity of patients recruited to CFS research studies.

NIH conference. Chronic fatigue syndrome research. Definition and medical outcome assessment.

It was viewed as essential for the investigator to screen for psychiatric disorder using a combination of self-report instruments followed by at least one structured interview to identify patients who should be excluded from studies or considered as a separate subgroup in data analysis.

Epidemiology of chronic fatigue syndrome: the Centers for Disease Control Study.

The US Centers for Disease Control initiated physician-based chronic fatigue syndrome (CFS) surveillance systems in four cities in September 1989 to determine the prevalence, incidence, course and

Fatigue syndromes: a comparison of chronic "postviral" fatigue with neuromuscular and affective disorders.

  • S. WesselyR. Powell
  • Psychology, Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1989
The fatigue in CFS appeared central in origin, suggesting it is not primarily a neuromuscular illness, and Attribution of symptoms to physical rather than psychological causes was the principal difference between matched CFS and psychiatric controls.

Definition and measurement of fatigue.

The natural history of chronic fatigue in its various clinical presentations is studied and that standardized assessment tools be used in this process, and the apparent association between affective illness and the chronic fatigue syndrome is addressed.