The Chromosomal Passenger Complex Is Required for Chromatin-Induced Microtubule Stabilization and Spindle Assembly

@article{Sampath2004TheCP,
  title={The Chromosomal Passenger Complex Is Required for Chromatin-Induced Microtubule Stabilization and Spindle Assembly},
  author={Srinath C. Sampath and Ryoma Ohi and Oliver Leismann and Adrian Salic and Andrei Pozniakovski and Hironori Funabiki},
  journal={Cell},
  year={2004},
  volume={118},
  pages={187-202}
}

Figures from this paper

Control of Chromosome Segregation by the Aurora B Complex

TLDR
It is demonstrated that Dasra proteins make the Aurora B pathway competent for chromatindependent activation, and provide a mechanism for the spatial regulation of spindle assembly.

The Chromosomal Passenger Complex Is Required for Meiotic Acentrosomal Spindle Assembly and Chromosome Biorientation

TLDR
It is proposed that the ring of CPC around the chromosomes regulates multiple aspects of meiotic cell division including spindle assembly, the establishment of bipolarity, the recruitment of important spindle organization factors, and the biorientation of homologous chromosomes.

The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions.

TLDR
It is shown that spindle checkpoint function of the CPC and its role in eliminating nonbipolar attachments can be uncoupled and that a mutant of this domain could restore alignment and cytokinesis during unperturbed cell divisions and was capable of resolving syntelic attachments.

Chromosome-directed oocyte spindle assembly depends HP1 and the Chromosomal Passenger Complex

TLDR
A strategy to manipulate the function and localization of INCENP is developed, which is critical for recruiting the Aurora B kinase, and an interaction between Borealin and HP1 is crucial for the initial recruitment of the CPC to the chromosomes and is sufficient to build kinetochores and recruit spindle microtubules.

Nucleosome functions in spindle assembly and nuclear envelope formation

  • C. ZierhutH. Funabiki
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2015
TLDR
The mechanisms by which nucleosomes control assembly and functions of the spindle and the NE are reviewed, and their implications for genome maintenance are discussed.

Highway to hell‐thy meiotic divisions: Chromosome passenger complex functions driven by microtubules

  • K. McKim
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2021
TLDR
CPC‐microtubule dependent functions are considered in the context of the first meiotic division and metaphase I error correction and subsequent bi‐orientation of bivalents may depend on microtubule associated CPC interacting with the kinetochores.

Survivin modulates microtubule dynamics and nucleation throughout the cell cycle.

TLDR
A model in which survivin modulates several mitotic events, including spindle and interphase microtubule organization, the spindle assembly checkpoint and cytokinesis through its ability to modulate microtubules nucleation and dynamics is proposed.

Dual recognition of chromatin and microtubules by INCENP is important for mitotic progression

TLDR
It is demonstrated that dual recognition of chromatin and microtubules by CPC is important for checkpoint maintenance and determination of cell fate in mitosis.
...

References

SHOWING 1-10 OF 96 REFERENCES

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

TLDR
It is shown that the activity of chromosome-associated RCC1 protein is required for spindle formation and a high local concentration of Ran-GTP around chromatin is proposed which in turn induces the local nucleation of microtubules.

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

TLDR
Borealin is described and results implicate the chromosomal passenger holocomplex in the maintenance of spindle integrity and suggest that histone H3 serine10 phosphorylation is performed by an Aurora B-INCENP subcomplex.

Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.

TLDR
The results show that MCAK regulation of cytoplasmic and spindle-associated microtubules can be differentiated by Aurora B-dependent phosphorylation, and they further demonstrate that this regulation is required for bipolar meiotic spindle assembly.

Correcting improper chromosome–spindle attachments during cell division

TLDR
By removal of small-molecule inhibitors, controlled activation of Aurora kinase during mitosis can correct chromosome attachment errors by selective disassembly of kinetochore–microtubule fibres, rather than by alternative mechanisms involving initial release of microtubules from either Kinetochores or spindle poles.

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

TLDR
The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.

TLDR
It is shown that the mitotic role of Ran is largely mediated by the nuclear transport factor importin beta, and it is proposed that RanGTP functions in mitosis as in interphase by locally releasing cargoes from transport factors.

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

The small GTPase Ran, bound to GTP, is required for the induction of spindle formation by chromosomes in M phase. High concentrations of Ran.GTP are proposed to surround M phase chromatin. We show
...