The Chromosomal Basis of Cancer

@article{Duesberg2005TheCB,
  title={The Chromosomal Basis of Cancer},
  author={P. Duesberg and R. Li and A. Fabarius and R. Hehlmann},
  journal={Cellular Oncology : the Official Journal of the International Society for Cellular Oncology},
  year={2005},
  volume={27},
  pages={293 - 318}
}
  • P. Duesberg, R. Li, +1 author R. Hehlmann
  • Published 2005
  • Biology, Medicine
  • Cellular Oncology : the Official Journal of the International Society for Cellular Oncology
  • Conventional genetic theories have failed to explain why cancer (1) is not heritable and thus extremely rare in newborns, (2) is caused by non-mutagenic carcinogens, (3) develops only years to decades after initiation by carcinogens, (4) follows pre-neoplastic aneuploidy, (5) is aneuploid, (6) is chromosomally and phenotypically “unstable”, (7) carries specific aneusomies, (8) generates much more complex phenotypes than conventional mutation such as multidrug resistance, (9) generates… CONTINUE READING
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    References

    SHOWING 1-10 OF 381 REFERENCES
    Aneuploidy and cancer: from correlation to causation.
    • 90
    • PDF
    Aneuploidy precedes and segregates with chemical carcinogenesis.
    • 123
    • PDF
    Aneuploidy, the somatic mutation that makes cancer a species of its own.
    • 223
    • PDF
    The origin of point mutations in human tumor cells.
    • 154
    • PDF
    Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells.
    • 57
    • PDF
    Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy.
    • 138
    • PDF
    Genetic disorders associated with cancer predisposition and genomic instability.
    • 72
    • Highly Influential
    Aneuploidy and cancer
    • S. Sen
    • Medicine
    • Current opinion in oncology
    • 2000
    • 549
    Destructive cycles: the role of genomic instability and adaptation in carcinogenesis.
    • 67
    • Highly Influential
    • PDF