The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine

@article{Mccleane2003TheCA,
  title={The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine},
  author={G. Mccleane},
  journal={The Clinical Journal of Pain},
  year={2003},
  volume={19},
  pages={200-201}
}
  • G. Mccleane
  • Published 2003
  • Medicine
  • The Clinical Journal of Pain
  • AimTo investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine. MethodA double-blind, placebo-controlled crossover study of 30 adult subjects. ResultsMean pain scores fell from a baseline of 8.12–7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor. ConclusionThe CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine. 

    Topics from this paper.

    Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance
    • 176
    • Open Access
    Endogenous opiates and behavior: 2003
    • 42
    Pharmacological strategies in relieving neuropathic pain
    • 20
    Strategies to reduce morphine tolerance in cancer : evaluation of the bifunctional opioid UFP-505
    • 3
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 13 REFERENCES
    Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide
    • 155
    The CCK-B receptor antagonist Cl 988 reverses tolerance to morphine in rats.
    • 54