The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine

  title={The Cholecystokinin Antagonist Proglumide Enhances the Analgesic Effect of Dihydrocodeine},
  author={G. Mccleane},
  journal={The Clinical Journal of Pain},
  • G. Mccleane
  • Published 2003
  • Medicine
  • The Clinical Journal of Pain
  • AimTo investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine. MethodA double-blind, placebo-controlled crossover study of 30 adult subjects. ResultsMean pain scores fell from a baseline of 8.12–7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor. ConclusionThe CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine. 

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