The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital Tract.

@article{Yang2016TheCP,
  title={The Chlamydia-Secreted Protease CPAF Promotes Chlamydial Survival in the Mouse Lower Genital Tract.},
  author={Zhangsheng Yang and Lingli Tang and Lili Shao and Yuyang Zhang and Tianyuan Zhang and Robert S. Schenken and Raphael H Valdivia and Guangming Zhong},
  journal={Infection and immunity},
  year={2016},
  volume={84 9},
  pages={
          2697-702
        }
}
Despite the extensive in vitro characterization of CPAF (chlamydial protease/proteasome-like activity factor), its role in chlamydial infection and pathogenesis remains unclear. We now report that a Chlamydia trachomatis strain deficient in expression of CPAF (L2-17) is no longer able to establish a successful infection in the mouse lower genital tract following an intravaginal inoculation. The L2-17 organisms were cleared from the mouse lower genital tract within a few days, while a CPAF… CONTINUE READING

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