The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.

@article{Graves2000TheCP,
  title={The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.},
  author={Paul R. Graves and Lifang Yu and Julie K. Schwarz and J. Gales and Edward A. Sausville and Patrick M. O'Connor and Helen Piwnica-Worms},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 8},
  pages={5600-5}
}
A checkpoint operating in the G(2) phase of the cell cycle prevents entry into mitosis in the presence of DNA damage. UCN-01, a protein kinase inhibitor currently undergoing clinical trials for cancer treatment, abrogates G(2) checkpoint function and sensitizes p53-defective cancer cells to DNA-damaging agents. In most species, the G(2) checkpoint prevents the Cdc25 phosphatase from removing inhibitory phosphate groups from the mitosis-promoting kinase Cdc2. This is accomplished by maintaining… CONTINUE READING
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