The Chemotherapeutic Treatment of Gonorrhœa and its Complications


BEFORE the introduction of the sulphonamide group of drugs, the treatment of infections due to the gonococcus was largely confined to the use of urinary antiseptics, irrigations of the urethra, and treatment of complications as they arose. More recently, vaccines and gonococcal antitoxin were added to these time-honoured methods in the hope that possibly a more rapid and successful cure might be attained. Crean (1937) remarks, however, that none of these methods has made any notable change in the length of time it takes to cure an uncomplicated acute case. With the introduction of chemotherapy, however, a new era in the treatment of gonorrheea was ushered in. Despite the fact that the sulphonamides have now been in use for some three or four years, there is still considerable doubt on many aspects of the chemotherapeutic treatment of gonococcal infections, this doubt, in some cases, extending even to the question as to which is the most suitable preparation to use in the treatment of these conditions. There is still considerable doubt, too, as to the proper time for commencing chemotherapy: a number of authorities have advocated "delayed therapy," whereby chemotherapeutic treatment in acute gonorrhoea is withheld for some eight to twenty-one days in order to allow the body immunity mechanism to develop; during this waiting period, routine methods of treatment (i.e., urethral irrigations and vaccines) are carried out; other workers, on the other hand, commence chemotherapy as soon as the diagnosis of the disease has been established. Various schemes of dosage have been suggested, whilst difference of opinion still exists as to the total amount of the drug required and as to the total duration of treatment, whilst the vexed question of the advisability or otherwise of combining chemotherapy with routine methods of treatment has not been definitely settled. Before a satisfactory statement can be made with regard to these points, a number of considerations demand attention, of which not the least important is the choice of the drug itself. There is now little doubt that the most efficient sulphona-mide for use in gonococcal infections is M.&B. 693, and the present article is the outcome of an investigation made with that drug in the treatment of gonorrhoea in patients attending the Venereal Diseases Clinic at the Royal Victoria Hospital, Belfast. The cases investigated were mostly males, though the results obtained in a small series of female patients are also recorded. In …

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@article{McCann1940TheCT, title={The Chemotherapeutic Treatment of Gonorrhœa and its Complications}, author={J. Sydney McCann}, journal={The Ulster Medical Journal}, year={1940}, volume={9}, pages={79 - 93} }