The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity

@inproceedings{Biggins2014TheCA,
  title={The Chemical
Arsenal of Burkholderia pseudomallei Is Essential
for Pathogenicity},
  author={John B. Biggins and Hahk-Soo Kang and Melinda A. Ternei and David DeShazer and Sean F. Brady},
  booktitle={Journal of the American Chemical Society},
  year={2014}
}
Increasing evidence has shown that small-molecule chemistry in microbes (i.e., secondary metabolism) can modulate the microbe-host response in infection and pathogenicity. The bacterial disease melioidosis is conferred by the highly virulent, antibiotic-resistant pathogen Burkholderia pseudomallei (BP). Whereas some macromolecular structures have been shown to influence BP virulence (e.g., secretion systems, cellular capsule, pili), the role of the large cryptic secondary metabolome encoded… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 21 references

Journal of the American Chemical Society J. Am. Chem. Soc

Journal of the American Chemical Society J. Am. Chem. Soc • 2014

Biochemistry

C R Archer
Biochemistry • 2012

Semin. Hematol

E Moran, F Carbone, +3 authors A Nencioni
Semin. Hematol • 2012

Annu. Rev. Microbiol

E E Galyov, P J Brett, D Deshazer
Annu. Rev. Microbiol • 2010

Bachmann, A. S. Biochem. Pharmacol

C R Archer, D L Koomoa, +5 authors R Dudler
Bachmann, A. S. Biochem. Pharmacol • 2010

Appl. Environ. Microbiol

C M Lopez, D A Rholl, L A Trunck, H P Schweizer
Appl. Environ. Microbiol • 2009

Chembiochem

J Clerc, B I Florea, +7 authors M Kaiser
Chembiochem • 2009

J. Am. Chem. Soc

M Strieker, E M Nolan, C T Walsh, M A Marahiel
J. Am. Chem. Soc • 2009

J. Med. Chem

G L Challis
J. Med. Chem • 2008

J. Nat. Biotechnol

T Nguyen, K Ishida, +6 authors C Hertweck
J. Nat. Biotechnol • 2008

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