The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics

@article{Long2006TheCR,
  title={The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics},
  author={K. Long and J. Poehlsgaard and C. Kehrenberg and S. Schwarz and B. Vester},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2006},
  volume={50},
  pages={2500 - 2505}
}
  • K. Long, J. Poehlsgaard, +2 authors B. Vester
  • Published 2006
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT A novel multidrug resistance phenotype mediated by the Cfr rRNA methyltransferase is observed in Staphylococcus aureus and Escherichia coli. The cfr gene has previously been identified as a phenicol and lincosamide resistance gene on plasmids isolated from Staphylococcus spp. of animal origin and recently shown to encode a methyltransferase that modifies 23S rRNA at A2503. Antimicrobial susceptibility testing shows that S. aureus and E. coli strains expressing the cfr gene exhibit… CONTINUE READING
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