The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics

  title={The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics},
  author={K. Long and J. Poehlsgaard and C. Kehrenberg and S. Schwarz and B. Vester},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={2500 - 2505}
  • K. Long, J. Poehlsgaard, +2 authors B. Vester
  • Published 2006
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT A novel multidrug resistance phenotype mediated by the Cfr rRNA methyltransferase is observed in Staphylococcus aureus and Escherichia coli. The cfr gene has previously been identified as a phenicol and lincosamide resistance gene on plasmids isolated from Staphylococcus spp. of animal origin and recently shown to encode a methyltransferase that modifies 23S rRNA at A2503. Antimicrobial susceptibility testing shows that S. aureus and E. coli strains expressing the cfr gene exhibit… CONTINUE READING
    499 Citations
    The Order Bacillales Hosts Functional Homologs of the Worrisome cfr Antibiotic Resistance Gene
    • 30
    • PDF
    Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics
    • 3
    • PDF
    Genetic Environment and Stability of cfr in Methicillin-Resistant Staphylococcus aureus CM05
    • 55
    • PDF
    Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase Center
    • 64
    • PDF
    Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
    • 301
    • Highly Influenced
    • PDF
    Transferable Plasmid-Mediated Resistance to Linezolid Due to cfr in a Human Clinical Isolate of Enterococcus faecalis
    • 134
    • PDF
    Linezolid-Resistant Staphylococcus aureus Strain 1128105, the First Known Clinical Isolate Possessing the cfr Multidrug Resistance Gene
    • 19
    • PDF
    Distinction between the Cfr Methyltransferase Conferring Antibiotic Resistance and the Housekeeping RlmN Methyltransferase
    • 22
    • PDF


    A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503
    • 254
    Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E. coli.
    • 12
    Macrolide Resistance Conferred by Base Substitutions in 23S rRNA
    • 475
    • PDF
    Activity of linezolid against Gram-positive cocci possessing genes conferring resistance to protein synthesis inhibitors.
    • 81
    • PDF
    The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome
    • 119
    Distribution of Florfenicol Resistance Genes fexA and cfr among Chloramphenicol-Resistant Staphylococcus Isolates
    • 296
    • PDF
    Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants
    • 805
    • PDF
    Fine structure of the peptidyl transferase centre on 23 S-like rRNAs deduced from chemical probing of antibiotic-ribosome complexes.
    • 149