The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells

  title={The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells},
  author={Maria K Lehtinen and Mauro W. Zappaterra and Xin Chen and Yawei J. Yang and Anthony D. Hill and Melody P. Lun and Thomas P R Maynard and Dilenny M. Gonzalez and Seonhee Kim and Ping Ye and A Joseph D'ercole and Eric T. Wong and Anthony S Lamantia and Christopher A. Walsh},
Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical progenitor cells. We found that the cerebrospinal fluid (CSF), which contacts this apical domain, has an age-dependent effect on proliferation, much of which is attributable to Igf2… CONTINUE READING
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