The Cerebral Effects of Pancuronium and Atracurium in Halothane‐anesthetized Dogs

@article{Lanier1985TheCE,
  title={The Cerebral Effects of Pancuronium and Atracurium in Halothane‐anesthetized Dogs},
  author={W. Lanier and J. Milde and J. Michenfelder},
  journal={Anesthesiology},
  year={1985},
  volume={63},
  pages={589–597}
}
  • W. Lanier, J. Milde, J. Michenfelder
  • Published 1985
  • Medicine
  • Anesthesiology
  • Pancuronium decreases the minimal alveolar anesthetic concentration (MAC) of halothane in humans, while atracurium has a metabolite, laudanosine, which is a known cerebral stimulant. To determine if these muscle relaxants significantly alter cerebral function, their effects on cerebral metabolic rate (CMRO2), cerebral blood flow (CBF), intracranial pressure (ICP), EEG, and the cerebral energy state were studied in halothane-anesthetized dogs. Group A dogs (n = 6) were maintained at 0.86% end… CONTINUE READING
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