The Cerebral Cavernous Malformation signaling pathway promotes vascular integrity via Rho GTPases

Abstract

Cerebral cavernous malformation (CCM) is a common vascular dysplasia that affects both systemic and central nervous system blood vessels. Loss of function mutations in the CCM2 gene cause CCM. Here we show that targeted disruption of Ccm2 in mice results in failed lumen formation and early embryonic death through an endothelial cell autonomous mechanism. We… (More)
DOI: 10.1038/nm.1911

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Whitehead2009TheCC, title={The Cerebral Cavernous Malformation signaling pathway promotes vascular integrity via Rho GTPases}, author={Kevin J. Whitehead and Aubrey C. Chan and Sutip Navankasattusas and Wonshill Koh and Nyall R. London and Jing Ling and Anne H. Mayo and Stavros G. Drakos and Christopher K. R. T. Jones and Weiquan Zhu and Douglas A. Marchuk and George A. Davis and Dean Y. Li}, booktitle={Nature Medicine}, year={2009} }