The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation

@inproceedings{Conduit2014TheCP,
  title={The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation},
  author={Paul T. Conduit and Zhe Feng and Jennifer H. Richens and Janina Baumbach and Alan Wainman and Suruchi D. Bakshi and Jeroen Dobbelaere and Steven Johnson and Susan M Lea and Jordan W Raff},
  booktitle={Developmental cell},
  year={2014}
}
Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during mitosis-a process termed centrosome maturation. How centrosomes mature remains mysterious. Here, we identify a domain in Drosophila Cnn that appears to be phosphorylated by Polo/Plk1 specifically at centrosomes during mitosis. The phosphorylation promotes the assembly of a Cnn scaffold around the centrioles that is in constant flux, with… CONTINUE READING
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