The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling.

@article{Kwan2016TheCN,
  title={The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling.},
  author={Wanda Kwan and M Robustillo Cortes and Isaura M. Frost and Virginie Esain and Lindsay N. Theodore and Sarah Liu and Nadine Budrow and Wolfram Goessling and Trista E. North},
  journal={Cell stem cell},
  year={2016},
  volume={19 3},
  pages={
          370-82
        }
}
Hematopoietic stem and progenitor cell (HSPC) specification is regulated by numerous defined factors acting locally within the hemogenic niche; however, it is unclear whether production can adapt to fluctuating systemic needs. Here we show that the CNS controls embryonic HSPC numbers via the hypothalamic-pituitary-adrenal/interrenal (HPA/I) stress response axis. Exposure to serotonin or the reuptake inhibitor fluoxetine increased runx1 expression and Flk1(+)/cMyb(+) HSPCs independent of… CONTINUE READING
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