The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn

@inproceedings{Abraira2017TheCA,
  title={The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn},
  author={Victoria E. Abraira and Emily D. Kuehn and Anda M. Chirila and Mark W. Springel and Alexis A. Toliver and Amanda L. Zimmerman and Lauren L. Orefice and Kieran A. Boyle and Ling Bai and B. Jianbin Song and Karleena A. Bashista and Thomas G. O'Neill and Justin Zhuo and Connie Tsan and Jessica Hoynoski and Michael L Rutlin and Laura Kus and Vera Niederkofler and Masahiko Watanabe and Susan M Dymecki and Sacha B. Nelson and Nathaniel Heintz and D I Hughes and David D Ginty},
  booktitle={Cell},
  year={2017}
}
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes… CONTINUE READING

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