The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

@article{Gregori2012TheCA,
  title={The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells},
  author={S. Gregori and K. Goudy and M. Roncarolo},
  journal={Frontiers in Immunology},
  year={2012},
  volume={3}
}
The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that human Tr1 cells use to control immune responses and induce tolerance. In this review we outline the well known and newly discovered regulatory properties of human Tr1 cells and provide an in-depth comparison of the known suppressor mechanisms of Tr1 cells with FOXP3+ Treg… Expand
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