The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

@article{Gregori2012TheCA,
  title={The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells},
  author={S. Gregori and K. Goudy and M. G. Roncarolo},
  journal={Frontiers in Immunology},
  year={2012},
  volume={3}
}
  • S. Gregori, K. Goudy, M. G. Roncarolo
  • Published 2012
  • Biology, Medicine
  • Frontiers in Immunology
    • The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that human Tr1 cells use to control immune responses and induce tolerance. In this review we outline the well known and newly discovered regulatory properties of human Tr1 cells and provide an in-depth comparison of the known suppressor mechanisms of Tr1 cells with FOXP3+ Treg… CONTINUE READING
    View PDF
    116 Citations
    Highly Influential Citations
    10
    Background Citations
    53
    Methods Citations
    1

    Figures, Tables, and Topics from this paper

    Figures and Tables

    Explore Further: Topics Discussed in This Paper

    116 Citations
    Citation Type

    Citation Type

    Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.
    • 157
    Engineered T Regulatory Type 1 Cells for Clinical Application
    • 36
    • PDF
    Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance
    • 115
    • PDF
    Regulatory T cells in autoimmune neuroinflammation
    • 135
    • Highly Influenced
    Regulatory T cells and their roles in immune dysregulation and allergy
    • 76
    Type 1 regulatory T (Tr1) cells: from the bench to the bedside
    • 11
    Regulatory B-Cells in Transplantation
    • 4
    • PDF
    Clinical Outlook for Type-1 and FOXP3+ T Regulatory Cell-Based Therapy
    • 46
    • PDF
    Decreased number and impaired function of type 1 regulatory T cells in autoimmune diseases
    • 5
    Granulysin- and granzyme-dependent elimination of myeloid cells by therapeutic ova-specific type 1 regulatory T cells
    • 6

    References

    SHOWING 1-10 OF 209 REFERENCES
    The role of different subsets of T regulatory cells in controlling autoimmunity.
    • 349
    Control of Regulatory T Cell Development by the Transcription Factor Foxp3
    • 7,752
    • PDF
    IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells1
    • 238
    • PDF
    Regulatory T Cells and Immune Tolerance
    • 3,763
    A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • 3,912
    Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    • 518
    • Highly Influential
    • PDF
    Adenosine and Prostaglandin E2 Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells*
    • 123
    • PDF
    A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • 4,096
    Regulatory T Cells
    • 1,558
    A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells
    • 746