The Cellular Transfer of Cutaneous Hypersensitivity to Tuberculin in Man

@article{Lawrence1949TheCT,
  title={The Cellular Transfer of Cutaneous Hypersensitivity to Tuberculin in Man},
  author={H. Sherwood Lawrence},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1949},
  volume={71},
  pages={516 - 522}
}
  • H. Lawrence
  • Published 1949
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
Summary and Conclusion 1. It has been possible to passively transfer in 12 consecutive instances cutaneous tuberculin hypersensitivity to tuberculin negative human recipients by means of an intradermal injection of viable leucocytes obtained from the blood of tuberculin positive human donors. 2. The effort at the passive transfer of cutaneous tuberculin hypersensitivity was unsuccessful when the leucocytes used, in the transfer were obtained from tuberculin negative donors. 3. The induced… Expand
Transfer of delayed hypersensitivity. The role of blood transfusions in humans.
Passive transfer of delayed skin hypersensitivity to purified protein derivative of tuberculin (tuberculin PPD) in five recipients who previously had negative reactions to tuberculin after receivingExpand
Serum transfer of delayed cutaneous hypersensitivity to tuberculin in man.
TLDR
It is indicated that there is certain material in the serum of tuberculous patients responsible for the passive transfer of the tuberculin hypersentivity and support the writer's previous works 11,12 and hypothesis 15 that the serum alpha-2 globulin fraction which has been consistently found increased in humans with active tuberculosis could actually be the antibody of the delayed hypersensitivity having been released from the sensitive leukocytes at the time of interaction with specific antigen. Expand
THE TRANSFER IN HUMANSOF DELAYEDSKIN SENSITIVITY TO STREPTOCOCCAL M SUBSTANCE ANDTO TUBERCULIN WITH DISRUPTEDLEUCOCYTES
It is possible to transfer regularly immunologically specific, generalized skin sensitivity of the delayed type to tuberculin in animals (1, 2) and in human subjects (3, 4) by means of an injectionExpand
TRANSFER OF DELAYED HYPERSENSITIVITY TO DIPHTHERIA TOXIN IN MAN
TLDR
Evidence is presented which indicates that the transfer factor may be released from leucocyte suspensions under mild conditions in which most of the cells appear to remain morphologically intact. Expand
A study of leukocytic antibodies in allergic patients.
TLDR
It is concluded that leukocytes derived from the peripheral blood of specifically sensitive human donors contain an unknown substance responsible for the transfer of tuberculin sensitivity and do not contain skin-sensitizing antibody against ragweed pollen, penicillin, or horse serum which can be detected on passive transfer. Expand
Response in two groups of anergic patients to the transfer of leukocytes from sensitive donors.
TLDR
Leukocytes from sensitive donors were injected subcutaneously into patients with malignant lymphomas and 13 with lepromatous leprosy and it is possible to obtain partial reversal of the altered immunologic mechanisms in lePromatous patients by means of leukocyte transfer. Expand
Cell-mediated immunity in leprosy and transfer of delayed hypersensitivity reactions.
TLDR
The transfer of delayed hypersensitivity reactions to tuberculin, trichophytin, and lepromin was accomplished in lepromatous and indeterminate leprosy patients using viable lymphocytes from donors presenting positive reactions to these antigens. Expand
TRANSFER FACTOR APPLIED TO INTENSIFY THE CELL‐MEDIATED IMMUNOLOGICAL REACTIONS AGAINST MYCOBACTERIUM AVIUM
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The use of dialysable T F is reported on in the treatment of a patient Avith tuberculosis due to Mycobnctcrhim avUivi, who showed a positive skin reaction to tuberculin extracts from M. tuberculosis and M. aviiim. Expand
Passive transfer of tuberculin sensitivity to patients with sarcoidosis.
TLDR
The failure to react is not merely the result of absence of exposure to tuberculous infection, since patients with sarcoidosis proved unable to develop and maintain tuberculin sensitivity in normal fashion after BCG vaccination. Expand
Sensitivity to Tuberculin
TLDR
It is shown that sensitivity to tuberculin could be passively transferred by the intra-peritoneal or intravenous injection of white cell concentrates from sensitized animals and this finding has been confirmed by Lawrence2, who achieved passive transfer in the human by the intradermal injection ofwhite cells from Sensitized donors. Expand
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