The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells

@inproceedings{Zhang2013TheCS,
  title={The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells},
  author={Xiu-Xiu Zhang and Hong-dan Li and Song Xian Zhao and Liang Zhao and Huijuan Song and Guan Wang and Qing-Jun Guo and Zhi-Dong Luan and Rong-jian Su},
  booktitle={BioMed research international},
  year={2013}
}
Invasion is a major characteristic of hepatocellular carcinoma and one of the main causes of refractory to treatment. We have previously reported that GRP78 promotes the invasion of hepatocellular carcinoma although the mechanism underlying this change remains uncertain. In this paper, we explored the role of the cell surface GRP78 in the regulation of cancer cell invasion in hepatocellular carcinoma cells. We found that neutralization of the endogenous cell surface GRP78 with the anti-GRP78… CONTINUE READING
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