The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse.

@article{Lohnes2003TheCH,
  title={The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse.},
  author={David Lohnes},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2003},
  volume={25 10},
  pages={971-80}
}
  • David Lohnes
  • Published 2003 in
    BioEssays : news and reviews in molecular…
The vertebrate Cdx genes (Cdx1 Cdx2 and Cdx4 in the mouse) encode homeodomain transcription factors related to the Drosophila caudal gene. The vertebrate Cdx gene products have been implicated in the development of the posterior embryo. In particular, loss- and gain-of-function experiments suggest that Cdx members are direct regulators of Hox genes and likely impart posterior information, in part, through this mechanism. Several signaling molecules, notably retinoic acid (RA*) and members of… CONTINUE READING

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