The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis

@inproceedings{RodrguezFraticelli2010TheCG,
  title={The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis},
  author={Alejo E. Rodr{\'i}guez-Fraticelli and Silvia Vergarajauregui and Dennis J. Eastburn and Anirban Datta and Miguel A. Alonso and Keith E. Mostov and Fernando Mart{\'i}n-Belmonte},
  booktitle={The Journal of cell biology},
  year={2010}
}
Epithelial organs are made of tubes and cavities lined by a monolayer of polarized cells that enclose the central lumen. Lumen formation is a crucial step in the formation of epithelial organs. The Rho guanosine triphosphatase (GTPase) Cdc42, which is a master regulator of cell polarity, regulates the formation of the central lumen in epithelial morphogenesis. However, how Cdc42 is regulated during this process is still poorly understood. Guanine nucleotide exchange factors (GEFs) control the… CONTINUE READING
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