The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.

@article{DazMartnez2015TheCP,
  title={The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.},
  author={Laura A. D{\'i}az-Mart{\'i}nez and Wei Tian and Bing Li and Ross T. Warrington and Luying Jia and Chad A. Brautigam and Xuelian Luo and Hongtao Yu},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 4},
  pages={2431-43}
}
The spindle checkpoint ensures accurate chromosome segregation by monitoring kinetochore-microtubule attachment. Unattached or tensionless kinetochores activate the checkpoint and enhance the production of the mitotic checkpoint complex (MCC) consisting of BubR1, Bub3, Mad2, and Cdc20. MCC is a critical checkpoint inhibitor of the anaphase-promoting complex/cyclosome, a ubiquitin ligase required for anaphase onset. The N-terminal region of BubR1 binds to both Cdc20 and Mad2, thus nucleating MCC… CONTINUE READING
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