The CcpA regulon of Streptococcus suis reveals novel insights into the regulation of the streptococcal central carbon metabolism by binding of CcpA to two distinct binding motifs.

@article{Willenborg2014TheCR,
  title={The CcpA regulon of Streptococcus suis reveals novel insights into the regulation of the streptococcal central carbon metabolism by binding of CcpA to two distinct binding motifs.},
  author={J{\"o}rg Willenborg and Astrid de Greeff and Michael Jarek and Peter Valentin-Weigand and Ralph Goethe},
  journal={Molecular microbiology},
  year={2014},
  volume={92 1},
  pages={
          61-83
        }
}
Streptococcus suis (S. suis) is a neglected zoonotic streptococcus causing fatal diseases in humans and in pigs. The transcriptional regulator CcpA (catabolite control protein A) is involved in the metabolic adaptation to different carbohydrate sources and virulence of S. suis and other pathogenic streptococci. In this study, we determined the DNA binding characteristics of CcpA and identified the CcpA regulon during growth of S. suis. Electrophoretic mobility shift analyses showed promiscuous… CONTINUE READING

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