The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.

@article{Duan2004TheCF,
  title={The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.},
  author={Lei Duan and Alagarsamy Lakku Reddi and Amiya Kumar Ghosh and Manjari Dimri and Hamid Band},
  journal={Immunity},
  year={2004},
  volume={21 1},
  pages={7-17}
}
Regulation of tyrosine kinase-mediated cellular activation through antigen receptors is of great biological and practical significance. The evolutionarily conserved Cbl family ubiquitin ligases have emerged as key negative regulators of activated tyrosine kinase-coupled receptors, and their impaired function switches a normal immune response into autoimmunity. Cbl proteins facilitate the ubiquitinylation of activated tyrosine kinases and other signaling proteins and of the signaling chains of… CONTINUE READING