The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels

@article{Altier2011TheCS,
  title={The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels},
  author={Christophe Altier and Agust{\'i}n Garc{\'i}a-Caballero and Brett A. Simms and Haitao You and Lina Chen and Jan Walcher and H. William Tedford and Tamara Hermosilla and Gerald W Zamponi},
  journal={Nature Neuroscience},
  year={2011},
  volume={14},
  pages={173-180}
}
It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the plasma membrane, but the cellular mechanism by which this occurs has remained unclear. We found that the Cavβ subunit increased membrane expression of Cav1.2 channels by preventing the entry of the channels into the endoplasmic reticulum–associated protein degradation (ERAD) complex. Without Cavβ, Cav1.2 channels underwent robust ubiquitination by the RFP2 ubiquitin ligase and interacted with the… CONTINUE READING
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