The CatSper channel: a polymodal chemosensor in human sperm.

  title={The CatSper channel: a polymodal chemosensor in human sperm.},
  author={Christoph Brenker and Normann Goodwin and Ingo Weyand and Nachiket Dilip Kashikar and Masahiro Naruse and Miriam Kr{\"a}hling and Astrid M{\"u}ller and Ulrich Benjamin Kaupp and Timo Str{\"u}nker},
  journal={The EMBO journal},
  volume={31 7},
The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate Ca(2+) influx. Other factors including neurotransmitters, chemokines, and odorants also affect sperm function by changing [Ca(2+)](i). Several ligands, notably odorants, have been proposed to control Ca(2+) entry and motility via G protein-coupled… CONTINUE READING


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