The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations

Abstract

MicroRNAs (miRs) are a group of small non-coding RNAs that regulate transcriptional or post-transcriptional gene expression. The aim of the present study was to investigate the role of miR −1, −21 and −145 and their targets in cardiotoxicity-induced by DOX and pegylated liposomal DOX. BALB/c mice subjected to subcutaneous injection of C-26 tumor cells… (More)
DOI: 10.1007/s11095-017-2194-3

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@article{RazaviAzarkhiavi2017TheCM, title={The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations}, author={Kamal Razavi-Azarkhiavi and Mahmoud Reza Jaafari and Khalil Abnous and Bibi Marjan Razavi and Amirhossein Jafarian and Faezeh Vahdati Hassani and Kobra Shirani and Gholamreza Karimi}, journal={Pharmaceutical Research}, year={2017}, volume={34}, pages={1849-1856} }