The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine

@article{Kuka2012TheCE,
  title={The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine},
  author={J. Kuka and R. Vilskersts and H. Cirule and Marina Makrecka and O. Pugovi{\vc}s and I. Kalvinsh and M. Dambrova and E. Liepinsh},
  journal={Journal of Cardiovascular Pharmacology and Therapeutics},
  year={2012},
  volume={17},
  pages={215 - 222}
}
  • J. Kuka, R. Vilskersts, +5 authors E. Liepinsh
  • Published 2012
  • Medicine
  • Journal of Cardiovascular Pharmacology and Therapeutics
  • Mildronate, an inhibitor of l-carnitine biosynthesis and uptake, is a cardioprotective drug whose mechanism of action is thought to rely on the changes in concentration of l-carnitine in heart tissue. In the present study, we compared the cardioprotective effect of mildronate (100 mg/kg) and a combination of mildronate and l-carnitine (100 + 100 mg/kg) administered for 14 days with respect to the observed changes in l-carnitine level and carnitine palmitoyltransferase I (CPT-I)-dependent fatty… CONTINUE READING
    35 Citations
    Elevated vascular γ‐butyrobetaine levels attenuate the development of high glucose‐induced endothelial dysfunction
    • 9
    The Regulation of Energy Metabolism Pathways Through L-Carnitine Homeostasis
    • 9
    • PDF

    References

    SHOWING 1-10 OF 35 REFERENCES
    Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction
    • 67
    Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
    • 52
    Effects of long-term mildronate treatment on cardiac and liver functions in rats.
    • 27
    Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
    • 18
    • PDF
    Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism
    • 22
    Effect of inhibiting carnitine biosynthesis on male rat sexual performance
    • 24
    Mildronate: cardioprotective action through carnitine-lowering effect.
    • 121