The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine

  title={The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine},
  author={J. Kuka and R. Vilskersts and H. Cirule and Marina Makrecka and O. Pugovi{\vc}s and I. Kalvinsh and M. Dambrova and E. Liepinsh},
  journal={Journal of Cardiovascular Pharmacology and Therapeutics},
  pages={215 - 222}
  • J. Kuka, R. Vilskersts, +5 authors E. Liepinsh
  • Published 2012
  • Medicine
  • Journal of Cardiovascular Pharmacology and Therapeutics
  • Mildronate, an inhibitor of l-carnitine biosynthesis and uptake, is a cardioprotective drug whose mechanism of action is thought to rely on the changes in concentration of l-carnitine in heart tissue. In the present study, we compared the cardioprotective effect of mildronate (100 mg/kg) and a combination of mildronate and l-carnitine (100 + 100 mg/kg) administered for 14 days with respect to the observed changes in l-carnitine level and carnitine palmitoyltransferase I (CPT-I)-dependent fatty… CONTINUE READING
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