The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine

@article{Kuka2012TheCE,
  title={The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine},
  author={J. Kuka and R. Vilskersts and H. Cirule and Marina Makrecka and O. Pugovi{\vc}s and I. Kalvinsh and M. Dambrova and E. Liepinsh},
  journal={Journal of Cardiovascular Pharmacology and Therapeutics},
  year={2012},
  volume={17},
  pages={215 - 222}
}
  • J. Kuka, R. Vilskersts, +5 authors E. Liepinsh
  • Published 2012
  • Medicine
  • Journal of Cardiovascular Pharmacology and Therapeutics
    • Mildronate, an inhibitor of l-carnitine biosynthesis and uptake, is a cardioprotective drug whose mechanism of action is thought to rely on the changes in concentration of l-carnitine in heart tissue. In the present study, we compared the cardioprotective effect of mildronate (100 mg/kg) and a combination of mildronate and l-carnitine (100 + 100 mg/kg) administered for 14 days with respect to the observed changes in l-carnitine level and carnitine palmitoyltransferase I (CPT-I)-dependent fatty… CONTINUE READING
    View on SAGE
    cpt.sagepub.com
    35 Citations
    Background Citations
    8
    Methods Citations
    4
    Results Citations
    1
    35 Citations
    Citation Type

    Citation Type

    Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.
    • 14
    Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
    • 39
    • PDF
    A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function
    • 4
    A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis
    • 8
    • PDF
    Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
    • 14
    Elevated vascular γ‐butyrobetaine levels attenuate the development of high glucose‐induced endothelial dysfunction
    • 9
    Decrease in Long‐Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl‐GBB
    • 1
    Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency
    • 101
    The Regulation of Energy Metabolism Pathways Through L-Carnitine Homeostasis
    • 9
    • PDF
    Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury.
    • 4

    References

    SHOWING 1-10 OF 35 REFERENCES
    Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction
    • 67
    Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
    • 52
    Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat
    • 30
    Mildronate, a Regulator of Energy Metabolism, Reduces Atherosclerosis in apoE/LDLR–/– Mice
    • 34
    Effects of long-term mildronate treatment on cardiac and liver functions in rats.
    • 27
    Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
    • 18
    • PDF
    Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism
    • 22
    Effect of inhibiting carnitine biosynthesis on male rat sexual performance
    • 24
    Mildronate: cardioprotective action through carnitine-lowering effect.
    • 121
    Mildronate, a Novel Fatty Acid Oxidation Inhibitor and Antianginal Agent, Reduces Myocardial Infarct Size Without Affecting Hemodynamics
    • 44