The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs

@inproceedings{Schlesinger2011TheCT,
  title={The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs},
  author={Jenny Schlesinger and M. T. Schueler and Marcel Grunert and Jenny J. Fischer and Qin Zhang and Tammo Krueger and Martin Lange and Martje Toenjes and Ilona Dunkel and Silke R. Sperling},
  booktitle={PLoS genetics},
  year={2011}
}
The transcriptome, as the pool of all transcribed elements in a given cell, is regulated by the interaction between different molecular levels, involving epigenetic, transcriptional, and post-transcriptional mechanisms. However, many previous studies investigated each of these levels individually, and little is known about their interdependency. We present a systems biology study integrating mRNA profiles with DNA-binding events of key cardiac transcription factors (Gata4, Mef2a, Nkx2.5, and… CONTINUE READING
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