Pyrazine-2-carboxaldehyde Thiosemicarbazone (PCT), an Iron Eliminating Agent with Antitumor Activity
- F. A. French, A. E. Lewis, A. H. Sheena, E. J. Blanz, Jr.
- Federation Proc.,
3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which have demonstrable carcinostatic activity. The active compounds share several elec tronic, structural, and reactive features in common. They all contain the N*â€”N*-â€”S* tridentate ligand system.