The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry

@inproceedings{Ayoub2009TheCT,
  title={The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry},
  author={Nabieh Ayoub and Eeson Rajendra and Xinyi Su and Anand D. Jeyasekharan and Robert Mahen and Ashok R. Venkitaraman},
  booktitle={Current Biology},
  year={2009}
}
BACKGROUND The Rad51 recombinase assembles on DNA to execute homologous DNA recombination (HR). This process is essential to repair replication-associated genomic lesions before cells enter mitosis, but how it is started and stopped during the cell cycle remains poorly understood. Rad51 assembly is regulated by the breast cancer suppressor Brca2, via its evolutionarily conserved BRC repeats, and a distinct carboxy (C)-terminal motif whose biological function is uncertain. Using "hit-and-run… CONTINUE READING