The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out".

@article{Ludwig2018TheCM,
  title={The Carbohydrate-Insulin Model of Obesity: Beyond "Calories In, Calories Out".},
  author={David S Ludwig and Cara B. Ebbeling},
  journal={JAMA internal medicine},
  year={2018},
  volume={178 8},
  pages={
          1098-1103
        }
}
Despite intensive research, the causes of the obesity epidemic remain incompletely understood and conventional calorie-restricted diets continue to lack long-term efficacy. According to the carbohydrate-insulin model (CIM) of obesity, recent increases in the consumption of processed, high-glycemic-load carbohydrates produce hormonal changes that promote calorie deposition in adipose tissue, exacerbate hunger, and lower energy expenditure. Basic and genetic research provides mechanistic evidence… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Potential circadian and circannual rhythm contributions to the obesity epidemic in elementary school age children

  • International Journal of Behavioral Nutrition and Physical Activity
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Dietary Intervention Randomized Controlled Trial (DIRECT) The Carbohydrate-Insulin Model of Obesity Special Communication Clinical Review & Education jamainternalmedicine.com (Reprinted

I Shai, D Schwarzfuchs, Y Henkin
  • JAMA Internal Medicine Published online July
  • 2018

Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the association with genotype pattern or insulin secretion: the DIETFITS randomized clinical trial

CD Gardner, JF Trepanowski, LC Del Gobbo
  • JAMA
  • 2018

A review of the carbohydrate-insulin model of obesity

KD Hall
  • Eur J Clin Nutr
  • 2017