The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil

@article{Everaerts2011TheCR,
  title={The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil},
  author={W. Everaerts and M. Gees and Y. A. Alpizar and R. Farr{\'e} and C. Leten and A. Apetrei and I. Dewachter and F. Leuven and R. Vennekens and D. Ridder and B. Nilius and T. Voets and K. Talavera},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={316-321}
}
Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental models to induce pain and inflammation. The noxious effects of MO are currently ascribed to specific activation of the cation channel TRPA1 in nociceptive neurons. In contrast to this view, we show here that the capsaicin receptor TRPV1 has a surprisingly large contribution to aversive and pain responses and visceral irritation induced by MO. Furthermore, we found that this can be explained by previously… Expand
Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel.
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Better understanding of the pharmacological properties of TRPV1 and specific targeting of tissues may eventually lead to the development of clinically useful agents, as well as a comprehensive account on the activation and inactivation mechanisms and the structure-function relationship of TRpV1. Expand
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TLDR
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The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa
TLDR
All three relevant irritant receptors are functionally expressed in the oral mucosa and play their specific roles in inducing neurogenic inflammation and sensitization to heat and cold. Expand
Differential effects of lipopolysaccharide on mouse sensory TRP channels.
TLDR
The results show that, in addition to TRPA1, other TRP channels in sensory neurons can be targets of LPS, suggesting that they may contribute to trigger and regulate innate defenses against gram-negative bacterial infections. Expand
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TLDR
It is suggested that TRPV1 and TRPA1 stimulation in the peritoneum produces abdominal nociception that is mediated by sensory fibres activation. Expand
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