The Capping Domain in RalF Regulates Effector Functions

@inproceedings{Alix2012TheCD,
  title={The Capping Domain in RalF Regulates Effector Functions},
  author={Eric Alix and Laurent Chesnel and Brad J. Bowzard and Aimee Marie Tucker and A Delprato and Jacqueline Cherfils and David O. Wood and Richard A. Kahn and Craig R Roy},
  booktitle={PLoS pathogens},
  year={2012}
}
The Legionella pneumophila effector protein RalF functions as a guanine nucleotide exchange factor (GEF) that activates the host small GTPase protein ADP-ribosylation factor (Arf), and recruits this host protein to the vacuoles in which this pathogen resides. GEF activity is conferred by the Sec7 domain located in the N-terminal region of RalF. Structural studies indicate that the C-terminal region of RalF makes contacts with residues in the Sec7 domain important for Arf interactions… CONTINUE READING

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