The Capicua repressor--a general sensor of RTK signaling in development and disease.

@article{Jimnez2012TheCR,
  title={The Capicua repressor--a general sensor of RTK signaling in development and disease.},
  author={Gerardo Jim{\'e}nez and Stanislav Y. Shvartsman and Ze'ev Paroush},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 6},
  pages={1383-91}
}
Receptor tyrosine kinase (RTK) signaling pathways control multiple cellular decisions in metazoans, often by regulating the expression of downstream genes. In Drosophila melanogaster and other systems, E-twenty-six (ETS) transcription factors are considered to be the predominant nuclear effectors of RTK pathways. Here, we highlight recent progress in identifying the HMG-box protein Capicua (CIC) as a key sensor of RTK signaling in both Drosophila and mammals. Several studies have shown that CIC… CONTINUE READING
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Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains.

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