The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

@article{McMahon2001TheCB,
  title={The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.},
  author={Michael McMahon and Kyogo Itoh and Masahiko Yamamoto and Simon A. Chanas and Colin J. Henderson and Lesley I. McLellan and C. R. Wolf and Christophe Cavin and John Daniel Hayes},
  journal={Cancer research},
  year={2001},
  volume={61 8},
  pages={
          3299-307
        }
}
Northern blotting has shown that mouse small intestine contains relatively large amounts of the nuclear factor-E2 p45-related factor (Nrf) 2 transcription factor but relatively little Nrf1. Regulation of intestinal antioxidant and detoxication enzymes by Nrf2 has been assessed using a mouse line bearing a targeted disruption of the gene encoding this factor. Both Nrf2-/- and Nrf2+/+ mice were fed a control diet or one supplemented with either synthetic cancer chemopreventive agents [butylated… CONTINUE READING

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