The Candida albicans phospholipomannan induces in vitro production of tumour necrosis factor-alpha from human and murine macrophages.

@article{Jouault1994TheCA,
  title={The Candida albicans phospholipomannan induces in vitro production of tumour necrosis factor-alpha from human and murine macrophages.},
  author={Thierry Jouault and Annie Bernigaud and Guy Lepage and Pierre Andr{\'e} Trinel and Daniel Poulain},
  journal={Immunology},
  year={1994},
  volume={83 2},
  pages={268-73}
}
We have previously identified a Candida albicans 14,000-18,000 MW antigen reacting with anti-beta-1,2-linked oligomannosides antibodies as being a phospholipomannan (PLM). Because of the structural similarities between the C. albicans PLM and lipophosphoglycans from various microbial pathogens known to be potent tumour necrosis factor-alpha (TNF-alpha) inducers, we investigated the PLM ability to induce TNF-alpha. Incubation of human monocytic cells THP-1 with PLM led to dose-dependent… CONTINUE READING

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